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o-chlorobenzylidene malononitrile (CS)                                                            

o-chlorobenzylidene malononitrile (CS), a strong irritating riot control agent, was inserted into the Branch Davidian Mount Carmel compound near Waco, Texas,to induce the inhabitants to leave the building. The insertion of CS started at 6.00 a.m. on April 19, 1993. Shortly after noon fire broke out and destroyed the
whole compound. Seventy-five Branch Davidians, including 28 children, died inside the building. The question arose whether CS gas or the interaction of CS and methylene chloride (MC) killed or contributed to the deaths of the Branch Davidians. I was asked by the OSC to answer this question and I prepared a report that tried to do so. My report is based on numerous documents and scientific literature provided to me by the OSC, on my own literature research, and on the report of Dr. Havens for the OSC on the CS and MC exposure scenario which might have occurred in the various rooms of the Mount Carmel building. The possible effects of methylene chloride on the group of Branch Davidians staying in the Mount Carmel compound on April 19, 1993, are dealt
with in Dr. George Lucier's report to the OSC.

There are various preparations of CS and various techniques to make CS airborne in an inhalable form. In Waco, a solution of CS in MC, contained in non-explosive projectiles and CO2 pressurized canisters, was used to insert the CS. Dispersed as droplets from this fluid, fine particles of crystalline CS emerged after instantaneous evaporation of MC. Experimental animals were exposed to CS to get information on toxic and lethal effects of CS. Most of these experiments reported in the literature were already conducted 30 - 40 years ago when there were no OECD and Good Laboratory Practice guidelines for standardized toxicity tests in experimental animals.

Furthermore, only one of these studies used MC/CS and the toxic potency of the various CS preparations (pulverized CS, molten CS, CS from thermal grenades) including CS dissolved in methylene chloride (MC/CS) was mostly different.

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