L-Ascorbic Phosphate Magnesium
(Magnesium
L-Ascorbic Acid -2-Phosphate) (VC-PMG) is a derivative
of L-ascorbic acid(AsA), white or slightly yellowish in
color and powdery in shape, odorless, tasteless and
hygroscopic, being stable in the light and air or when
heated. It dissolves in water and easily in dilute acid, but
not in ethanol, trichloromethane or aether and other organic
solvents. When entering the human or animal body, it
converts into L-ascorbic acid (vitamin C) through the
enzymolysis of phosphatase, and maintains the same
physiological function and biological efficacy as L-ascorbic
acid.Chemical name of VC-PMG is
L-ascorbyl-2-oxygen-magnesium phosphate, its molecular
formula is C6H6O9PMg3/2©q5H2O and its molecular weight is
379.62 (referring to the Standard of International Atomic
Weight).As indicated in the research, VC-PMG is a key
constituent of skin moisturizer able to effectively inhibit
the activity of tyrosinase in skin, facilitate the synthesis
of collagen, for example, the bone collagen may enable the
skin to become soft, flexible and with less wrinkles. VC-PMG
may also resist the damage caused on the skin due to the U.V.
light, smog and other environmental effects. Besides , it is
known to all that VC-PMG can be used for reduction of
intermediates in the melanin and to stop the oxidizing
reaction of DOPA to melanin; being one of the seven
whitening agents popular worldwide for facial make-up. In
the food industry, VC-PMG is widely used even in the
functional food, and particularly in the food for the old,
children and for military use. The success application of
VC-PMG has been seen in the industries of brewing and
healthcare products.
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Effect
of
L-ascorbic acid phosphate magnesium (APM) on
chicks injected radical initiator,
2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH),
was examined. Chicks were fed APM as ascorbate
resource for 7 days. Birds were administrated AAPH
by intraperitoneal injection after APM feeding. The
changes of ascorbate and thiobarbituric acid
reactive substances (TBARS) in plasma and liver were
determined before, and 3 and 6 hours after AAPH
injection. Both plasma and liver ascorbate increased
by APM feeding. After AAPH injection, liver
ascorbate decreased, but plasma ascorbate increased
in both control and APM-fed birds. AAPH
administration raised liver TBARS, but decreased
plasma TBARS. Both plasma and liver TBARS were lower
in APM group than control group before and after
AAPH administration. Peroxyl radical trapping
activity in plasma was elevated by APM feeding as
compared to control group. APM was utilized as
ascorbate, and was effective for prevention of
oxidative stresses derived from AAPH by increasing
plasma and liver ascorbate and plasma radical
trapping activity. (author abst.)
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